Botulinum toxin – how a poison turned to a fascinating ally against an old adversary

Toxina botulínica – de como um veneno transformou-se num fascinante aliado contra um velho adversário

Elizabeth M. A. Barasnevicius Quagliato

The clinical features of dystonia were first reported in 1911, when Oppehneim1 and Flatau2 described some Jewish children affected by a syndrome, that was retrospectively considered to represent familial cases of DYT1 dystonia. In 1975 it was recognized that the dystonia phenotype also encompasses poorly-progressive focal and segmental cases with onset in adulthood, such as blepharospasm, cervical dystonia (CD) and writer’s cramp3. A modern definition of dystonia was worded some years later, in 19844,5.

Faça o download do artigo completo

Toxina Botulínica / Botox